Reading GO enrichment object

en_head = readRDS(here::here('data/enGo_head.Rds'))

Level 3 blocks

goplot_list = llply(en_head$summary$Name[en_head$summary$Nested_Level==3],
                    XGR_plot, en_head$XGR, en_head$summary)
## [1] "0-0"
## [1] "1-1"
## [1] "2-1"
## [1] "3-0"
## [1] "4-0"
names(goplot_list) = en_head$summary$Name[en_head$summary$Nested_Level==3]

0-0 - Neuro and sensing

1-1 - Translation, protein transport, immune response

2-1 - Sugar metabolism, proteolysis, Krebs Cycle

3-0 - Development, transcription, splicing, cell respiration

4-0 - Muscle delevelopment, krebs cycle

Probing some interesting blocks

Neuro

0-0-0

## [1] "0-0-0"

Overall: Gorilla 0-0-0

  • 24 - Biological regulation, signal transduction, cell component assembly, neuro development Gorilla
  • 17 - Regulation of cellular process Gorilla
  • 7 - phototransduction, detection of light stimulus, G protein-coupled receptor signaling pathway Gorilla
  • 3 - RNA processing Gorilla
  • 0 - neuropeptide signaling pathway, synaptic vesicle [transport|localization|exocytosis], synapse Gorilla

12-0-0

## [1] "12-0-0"

Overall: Gorilla 12-0-0

  • 29 - trans-synaptic signaling Gorilla
  • 37 - [cell|neuron] recognition Gorilla
  • 48 - [reproductive|mating] behavior Gorilla
  • 53 - Nada! Zilch! Nothing! Gorilla

Translation

1-1-1

## [1] "1-1-1"

Overall: Gorilla 1-1-1

  • 1 - macromolecule biosynthetic process, translation Gorilla
  • 9 - cytoplasmic translation Gorilla
  • 33 - cytoplasmic translation, rRNA processing Gorilla
  • 35 - translation, [peptide|peptide] biosynthetic process, ribosomal large subunit assembly Gorilla

6-1-1

## [1] "6-1-1"

Overall: Gorilla 6-1-1

  • 8 - translational initiation Gorilla
  • 14 - translation, [peptide|peptide biosynthetic process] biosynthetic process, ribonucleoprotein complex subunit organization Gorilla
  • 44 - cytoplasmic translation Gorilla
  • 49 - nucleobase-containing small molecule biosynthetic process (super weak) Gorilla

Immune response

10-1-1

## [1] "10-1-1"

Overall: Gorilla 10-1-1

  • 15 - establishment of protein localization, protein transport Gorilla
  • 22 - protein targeting to membrane, translocation Gorilla
  • 52 - response to other organism, response to external biotic stimulus, defense response Gorilla

Cell respiration

11-3-0

## [1] "11-3-0"

Overall: Gorilla 11-3-0

  • 20 - electron transport chain, generation of precursor metabolites and energy, oxidation-reduction process, mitochondrial respiratory chain complex assembly Gorilla
  • 21 - multicellular organism reproduction (weak) Gorilla
  • 26 - purine ribonucleotide biosynthetic process, ATP biosynthetic process, ATP metabolic process, acyl-CoA biosynthetic process Gorilla

Development

7-3-0

## [1] "7-3-0"

Overall: Gorilla 7-3-0

  • 11 - apposition of dorsal and ventral imaginal disc-derived wing surfaces, sarcomere organization, proton transmembrane transport Gorilla
  • 27 - anatomical structure morphogenesis, developmental process Gorilla
  • 51 - Nothing Gorilla

Transcription and protein metabolism

Protein Catabolism

## [1] "4-3-0"

Overall: Gorilla 4-3-0

  • 5 - protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, mRNA splicing Gorilla
  • 50 - superoxide metabolic process (weak) Gorilla

Translation (and some weird misc)

## [1] "3-3-0"

Overall: Gorilla 3-3-0

  • 4 - Largest block (500 genes) - nucleic acid metabolic process, RNA metabolic process, regulation of gene expression Gorilla
  • 25 - renal filtration (weak) Gorilla
  • 28 - regulation of macromolecule metabolic process, regulation of gene expression , mRNA splicing Gorilla
  • 31 - axon guidance, cell recognition, neuron projection guidance Gorilla
  • 34 - extracellular matrix organization (weak) Gorilla
  • 40 - chitin metabolic process, chitin metabolic process (weak) Gorilla
  • 43 - basement membrane organization, cell-substrate adhesion (weak) Gorilla
  • 55 - immune response, humoral immune response, defense response to bacterium Gorilla

Block summary table:

dplyr::select(en_head$summary, Nested_Level, Name, N_genes, Internal_degree, Assortatitvity,  p.adjust, n_enrich)